Your shopping cart is empty!
Product Category: | Knockdown Validated Polyclonal Antibody |
Synonyms: | Nuclear Receptor Subfamily 3 Group C Member 1;Glucocorticoid Receptor; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) ; GRL; GR; Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(54) ;Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(77) ; Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(93) ; Nuclear Receptor Subfamily 3, Group C, Member 1; Glucocorticoid Nuclear Receptor Variant 1; GCRST;GCCR; GCR |
UniProt Entry: | P04150 |
NCBI Gene Entry: | 2908 |
Molecular Weight: | 91,94 kDa |
Clonality: | Rabbit polyclonal antibody |
Species Reactivity: | Human |
Applications: | WB/IC/F |
Recommended Dilution: | WB 1:1000 / IC 1:100 / F 1:100 |
Immunogen: | Recombinant fragment of human NR3C1 |
Isotype: | Rabbit IgG |
Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
Storage: | At –20°C |
Background: | NR3C1 gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. |
Documents: | Please contact us to request the manual |